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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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LIBS光谱技术鉴别原料药或辅料中的金属元素

Identification of metal elements in APIs and excipients by LIBS

作者(英文):
分类号:R917
出版年·卷·期(页码):2019,39 (3):557-564
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:建立简便、快速鉴别原料药或药用辅料中金属元素的激光诱导击穿光谱法(LIBS)。方法:以择几种含钠、钾、镁、钙、锌元素的原料药或药用辅料为模型,采用LIBS采集样品的原子光谱,基于原子光谱理论和NIST数据库,对166~800 nm波段范围内LIBS谱线进行辨识,鉴别样品中的金属元素。结果:获得的LIBS光谱中的特征谱线与样品中的金属元素一一对应。结论:LIBS光谱法是鉴别药物或药用辅料中金属元素的快速、准确、可靠的方法。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To establish a simple and rapid method to identify metal elements in active pharmaceutical ingredients (APIs) or pharmaceutical excipients by laser-induced breakdown spectroscopy (LIBS). Methods: Select several APIs or pharmaceutical excipients containing Na,K,Mg,Ca,Zn as models,and collect their LIBS spectra in 166-800 nm wavelength range.Based on the theoretical knowledge of atomic spectroscopy and the NIST database,spectra analysis,the metal elements existing in the samples were identified. Results: The characteristic spectral lines obtained from the LIBS spectra correspond to the metal elements in the samples. Conclusion: LIBS technique can be used as a rapid,accurate and reliable method for identification of metal elements in APIs and excipients.

-----参考文献:---------------------------------------------------------------------------------------

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