关闭
 
读者在线:用户名 密码
首页 期刊简介 投稿须知 期刊目录 专家风采 编委会 特邀顾问 联系我们 移动出版
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5



刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

访问统计
您是第  3 8 7 7 5 6 1 位浏览者
您当前的位置:首页 >> 正文

卡马西平与氢氯噻嗪共晶的表征与性质的研究

Characterization of the properties of carbamazepine and hydrochlorothiazide cocrystal

作者(英文):
分类号:R917
出版年·卷·期(页码):2018,38 (10):1842-1849
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:制备卡马西平与氢氯噻嗪共晶,并对共晶的性质进行研究。方法:采用溶液结晶法制备卡马西平与氢氯噻嗪共晶,通过X-射线单晶衍射法(SCXRD)、X-射线粉末衍射法(PXRD)、差示扫描量热法(DSC)、热重分析(TGA)、红外光谱法(IR)对共晶进行表征,并通过HPLC对共晶的溶解度以及在人工胃液中、水中,在高温、高湿、光照条件下的稳定性进行考察;同时考察共晶在高湿条件下的吸湿性。结果:在75%、90%的高湿条件下,卡马西平与氢氯噻嗪的物理混合物10 d的吸湿性分别为0.022 9%、0.028 0%,共晶的吸湿性分别为0.003 5%、0.004 0%;在光照条件下,卡马西平、氢氯噻嗪10 d产生的杂质含量为0.36%、0.13%,共晶中的卡马西平、氢氯噻嗪10 d产生的杂质含量为0.13%、0.00%;在水中的溶解度,共晶中的卡马西平比原料药卡马西平的溶解度提高约1倍。结论:卡马西平和氢氯噻嗪形成共晶可以降低药物在高湿条件下的吸湿性,同时对原料药在光照条件下的稳定性有小幅度提高,并提高了卡马西平在水中溶解度。

-----英文摘要:---------------------------------------------------------------------------------------

Objective:To prepare carbamazepine and hydrochlorothiazide cocrystal and to study its properties. Methods:The carbamazepine and hydrochlorothiazide cocrystal was prepared by using the solution crystallization method. Then the cocrystal was characterized by X-ray single crystal diffraction (SCXRD), X-ray powder diffraction(PXRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and infrared spectroscopy (IR). In addition, the solubility of the cocrystal and the stability (including in artificial gastric juice, in water, high temperature, high humidity and light) of the cocrystal were analyzed by high performance liquid chromatography. Simultaneously, the hygroscopicity of the cocrystal under high humidity conditions was investigated. Results:Under 75% and 90% humidity, the hygroscopicity of the physical mixture of carbamazepine and hydrochlorothiazide was 0.022 9% and 0.028 0%, respectively;the hygroscopicity of the cocrystal was 0.003 5% and 0.004 0%, respectively. Under light conditions, the contents of impurities produced by carbamazepine and hydrochlorothiazide were 0.36%, and 0.13% after 10 days;the contents of impurities in cocrystal were 0.13% and 0.00%. In water, the solubility of carbamazepine in cocrystal was about 1 times higher than that of the drug substance carbamazepine. Conclusion:Formation of cocrystal of carbamazepine and hydrochlorothiazide can reduce the hygroscopicity of the drug under high humidity conditions. At the same time, the cocrystal slightly improves the stability of the drug substance under light conditions and improves the solubility of carbamazepine in water.

-----参考文献:---------------------------------------------------------------------------------------

欢迎阅读《药物分析杂志》!您是该文第 591位读者!

药物分析杂志 © 2009
地址:北京天坛西里2号
邮政编码:100050; 技术支持:010-60213898

电子邮件:ywfx@nicpbp.org.cn