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期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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敞开式离子化质谱及其在体内药物分析中的应用

Ambient mass spectrometry and its application in biopharmaceutical analysis

作者: 龚欢, 葛庆华 
作者(英文):
分类号:R917
出版年·卷·期(页码):2017,37 (1):1-12
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

敞开式离子化质谱是近十年来逐渐新兴的一种无需对样品进行复杂前处理或色谱分离,在常温常压环境下直接通过质谱分析样品中痕量物质信息的新型质谱技术。该技术极大地提高了质谱分析效率,使得原位实时快速分析样品成为可能,并在食品安全、环境监测、生物医药等领域得到广泛应用。本文系统综述包括解吸电喷雾电离、纸喷雾电离、实时直接分析等典型敞开式离子化质谱的基本原理与操作方法,述评各技术在体内药物分析领域的典型应用,并展望敞开式离子化质谱技术的应用前景。

-----英文摘要:---------------------------------------------------------------------------------------

Ambient mass spectrometry has evolved as a novel type of mass spectrometry techniques in the past decade,which is used to analyze the trace substance in the sample directly under normal temperature and pressure without any complicated pretreatment or chromatographic separation.With high efficiency and low expense,this technology has acquired widespread applications in food safety,environmental surveillance,bioanalysis and other fields.In this paper,the mechanisms and manipulations of typical ambient ionization techniques in details,such as desorption electrospray ionization,paper spray ionization and direct analysis in real time, are summarized.Furthermore,the applications in biopharmaceutical analysis are reviewed.

-----参考文献:---------------------------------------------------------------------------------------

[1] TAKYI-WILLIAMS J,LIU CF,TANG K.Ambient ionization MS for bioanalysis:recent developments and challenges[J].Bioanalysis,2015,7(15):1901
[2] TAKATS Z,WISEMAN JM,GOLOGAN B,et al.Mass spectrometry sampling under ambient conditions with desorption electrospray ionization[J].Science,2004,306(5695):471
[3] GU H,XU N,CHEN H.Direct analysis of biological samples using extractive electrospray ionization mass spectrometry(EESI-MS)[J].Anal Bioanal Chem,2012,403(8):2145
[4] HIRAOKA K,NISHIDATE K,MORI K,et al.Development of probe electrospray using a solid needle[J].Rapid Commun Mass Spectrom,2007,21(18):3139
[5] WANG H,LIU J,GRAHAM CR,et al.Paper spray for direct analy-sis of complex mixtures using mass spectrometry[J].Angew Chem Int Ed Engl,2010,49(5):877
[6] CODY RB,LARAMEE JA,DURST HD.Versatile new ion source for the analysis of materials in open air under ambient conditions[J].Anal Chem,2005,77(8):2297
[7] PETUCCI C,DIFFENDAL J.Atmospheric solids analysis probe:a rapid ionization technique for small molecule drugs[J].J Mass Spectrom,2008,43(11):1565
[8] CHEN H,ZHENG J,ZHANG X,et al.Surface desorption atmos-pheric pressure chemical ionization mass spectrometry for direct ambient sample analysis without toxic chemical contamination[J].J Mass Spectrom,2007,42(8):1045
[9] HARPER JD,CHARIPAR NA,MULLIGAN CC,et al.Low-tem-perature plasma probe for ambient desorption ionization[J].Anal Chem,2008,80(23):9097
[10] SMOLUCH M,MIELCZAREK P,SILBERRING J.Plasma-based ambient ionization mass spectrometry in bioanalytical sciences[J].Mass Spectrom Rev,2016,35(1):22
[11] LEBEDEV AT.Ambient ionization mass spectrometry[J].Russian Chem Rev,2015,84(7):665
[12] DING X,DUAN Y.Plasma-based ambient mass spectrometry techniques:The current status and future prospective[J].Mass Spectrom Rev,2015,34(4):449
[13] 贺玖明,李铁钢,何菁菁,等.常压敞开式离子化质谱技术研究进展[J].分析测试学报,2012,31(9):1151 HE JM,LI TG,HE JJ,et al.Advances in ambient ionization mass spectrometry[J].J Instrum Anal,2012,31(9):1151
[14] KLAMPFL CW,HIMMELSBACH M.Direct ionization methods in mass spectrometry:an overview[J].Anal Chim Acta,2015,890:44
[15] 陈焕文,胡斌,张燮.复杂样品质谱分析技术的原理与应用[J].分析化学,2010,38(8):1069 CHEN HW,HU B,ZHANG X.Fundamental principles and practical applications of ambient ionization mass spectrometry for direct analysis of complex samples[J].Chin J Anal Chem,2010,38(8):1069
[16] COSTA AB,GRAHAM CR.Simulated splashes:Elucidating the mechanism of desorption electrospray ionization mass spectrometry[J].Chem Phys Lett,2008,464(1-3):1
[17] MURAMOTO S,FORBES TP,STAYMATES ME,et al.Visualizing mass transport in desorption electrospray ionization using time-of-flight secondary ion mass spectrometry[J].Analyst,2014,139(11):2668
[18] ROACH PJ,LASKIN J,LASKIN A.Nanospray desorption electros-pray ionization:an ambient method for liquid-extraction surface sampling in mass spectrometry[J].Analyst,2010,135(9):2233
[19] LU HY,ZHANG JY,ZHOU W,et al.Direct analysis of phos-pholipids in biological tissues using internal extractive electrospray ionization mass spectrometry[J].Chin J Anal Chem,2016,44(3):329
[20] LIU C,ZHANG X,XIAO S,et al.Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry[J].Talanta,2012,98:79
[21] LIU J,WANG H,MANICKE NE,et al.Development,characteriz-ation,and application of paper spray ionization[J].Anal Chem,2010,82(6):2463
[22] YANG Q,WANG H,MAAS JD,et al.Paper spray ionization devices for direct,biomedical analysis using mass spectrometry[J].Int J Mass Spectrom,2012,312:201
[23] ELLIS SR,BROWN SH,PANHUIS MIH,et al.Surface analysis of lipids by mass spectrometry:More than just imaging[J].Prog Lipid Res,2013,52(4):329
[24] GROSS JH.Direct analysis in real time-a critical review on DART-MS[J].Anal Bioanal Chem,2014,406(1):63
[25] SONG L,DYKSTRA AB,YAO H,et al.Ionization mechanism of negative ion-direct analysis in real time:a comparative study with negative ion-atmospheric pressure photoionization[J].J Am Soc Mass Spectrom,2009,20(1):42
[26] HORVATIC V,VADLA C,FRANZKE J.Discussion of fundamental processes in dielectric barrier discharges used for soft ionization[J].Spectrochim Acta Part B,2014,100:52
[27] ALBERT A,ENGELHARD C. Characteristics of low-temperature plasma ionization for ambient mass spectrometry compared to electrospray ionization and atmospheric pressure chemical ionization[J].Anal Chem,2012,84(24):10657
[28] ROSSI A,CASTRATI L,COLOMBO P,et al.Development and validation of a DESI-HRMS/MS method for the fast profiling of esomeprazole and its metabolites in rat plasma:a pharmacokinetic study[J].Drug Test Anal,2016,8(2):208
[29] SONG Y,LIAO J,ZHA C,et al.A novel approach to determine the tyrosine concentration in human plasma by DART-MS/MS[J].Anal Methods,2015,7(4):1600
[30] SWALES JG,TEMESI DG,DENN M,et al.Determination of paracetamol in mouse,rat and dog plasma samples by laser diode thermal desorption-APCI-MS/MS[J].Bioanalysis 2012,4(11):1327
[31] JOURDIL JF,PICARD P,MEUNIER C,et al.Ultra-fast cyclosporin A quantitation in whole blood by laser diode thermal desorption-tandem mass spectrometry;comparison with high performance liquid chromatography-tandem mass spectrometry[J].Anal Chim Acta,2013,805:80
[32] SIEBENHAAR M,KÜLLMER K,de BARROS FERNANDES NM,et al.Personalized monitoring of therapeutic salicylic acid in dried blood spots using a three-layer setup and desorption electrospray ionization mass spectrometry[J].Anal Bioanal Chem,2015,407(23):7229
[33] MANICKE NE,ABU-RABIE P,SPOONER N,et al.Quantitative analysis of therapeutic drugs in dried blood spot samples by paper spray mass spectrometry:an avenue to therapeutic drug monitoring[J].J Am Soc Mass Spectrom,2011,22(9):1501
[34] ZHANG Z,XU W,MANICKE NE,et al.Silica coated paper substrate for paper-spray analysis of therapeutic drugs in dried blood spots[J].Anal Chem,2012,84(2):931
[35] LI X,FANG X,YU Z,et al.Direct quantification of creatinine in human urine by using isotope dilution extractive electrospray ionization tandem mass spectrometry[J].Anal Chim Acta,2012,748:53
[36] CARRIZO D,NERIN I,DOMENO C,et al.Direct screening of tobacco indicators in urine and saliva by atmospheric pressure solid analysis probe coupled to quadrupole-time of flight mass spectrometry (ASAP-MS-Q-TOF-)[J].J Pharm Biomed Anal,2016,124:149
[37] THUNIG J,FLO L,PEDERSEN-BJERGAARD S,et al.Liquid-phase microextraction and desorption electrospray ionization mass spectrometry for identification and quantification of basic drugs in human urine[J].Rapid Commun Mass Spectrom,2012,26(2):133
[38] RODRIGUEZ-LAFUENTE A,MIRNAGHI FS,PAWLISZYN J.Determination of cocaine and methadone in urine samples by thin-film solid-phase microextraction and direct analysis in real time (DART) coupled with tandem mass spectrometry[J].Anal Bioanal Chem,2013,405(30):9723
[39] JACKSON AU,GARCIA-REYES JF,HARPER JD,et al.Analysis of drugs of abuse in biofluids by low temperature plasma (LTP) ionization mass spectrometry[J].Analyst,2010,135(5):927
[40] ZAITSU K,HAYASHI Y,MURATA T,et al.Intact endogenous metabolite analysis of mice liver by probe electrospray ionization/triple quadrupole tandem mass spectrometry and its preliminary application to in vivo real-time analysis[J].Anal Chem,2016,88(7):3556
[41] YOSHIMURA K,CHEN LC,JOHNO H,et al.Development of non-proximate probe electrospray ionization for real-time analysis of living animal[J].Mass Spectrom (Tokyo),2014,3(Spec Iss 3):S0048
[42] HSU CC,DORRESTEIN PC. Visualizing life with ambient mass spectrometry[J].Curr Opin Biotechnol,2015,31:24
[43] NEMES P,VERTES A.Ambient mass spectrometry for in vivo local analysis and in situ molecular tissue imaging[J].TrAC Trend Anal Chem,2012,34:22
[44] SANTAGATA S,EBERLIN LS,NORTON I,et al.Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery[J].Proc Natl Acad Sci USA,2014,111(30):11121
[45] ABBASSI-GHADI N,VESELKOV K,KUMAR S,et al.Discrimin-ation of lymph node metastases using desorption electrospray ionisation-mass spectrometry imaging[J].Chem Commun,2014,50(28):3661
[46] EBERLIN LS,TIBSHIRANI RJ,ZHANG J,et al.Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging[J].Proc Natl Acad Sci USA,2014,111(7):2436
[47] D'ALVISE J,MORTENSEN R,HANSEN SH,et al.Detection of follicular transport of lidocaine and metabolism in adipose tissue in pig ear skin by DESI mass spectrometry imaging[J].Anal Bioanal Chem,2014,406(15):3735
[48] LIU J,GINGRAS J,GANLEY KP,et al.Whole-body tissue distri-bution study of drugs in neonate mice using desorption electrospray ionization mass spectrometry imaging[J].Rapid Commun Mass Spectrom,2014,28(2):185
[49] CALLIGARIS D,CARAGACIANU D,LIU X,et al.Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis[J].Proc Natl Acad Sci USA,2014,111(42):15184
[50] OTSUKA Y,NAITO J,SATOH S,et al.Imaging mass spectrometry of a mouse brain by tapping-mode scanning probe electrospray ionization[J].Analyst,2014,139(10):2336
[51] KERIAN KS,JARMUSCH AK,PIRRO V,et al.Differentiation of prostate cancer from normal tissue in radical prostatectomy specimens by desorption electrospray ionization and touch spray ionization mass spectrometry[J].Analyst,2015,140(4):1090
[52] GUENTHER S,MUIRHEAD LJ,SPELLER AV,et al.Spatially resolved metabolic phenotyping of breast cancer by desorption electrospray ionization mass spectrometry[J].Cancer Res,2015,75(9):1828
[53] CALLIGARIS D,FELDMAN DR,NORTON I,et al.Molecular typing of meningiomas by desorption electrospray ionization mass spectrometry imaging for surgical decision-making[J].Int J Mass Spectrom,2015,377:690
[54] HSU CC,CHOU PT,ZARE RN.Imaging of proteins in tissue samples using nanospray desorption electrospray ionization mass spectrometry[J].Anal Chem,2015,87(22):11171
[55] OTSUKA Y,SATOH S,NAITO J,et al.Visualization of cancer-related chemical components in mouse pancreas tissue by tapping-mode scanning probe electrospray ionization mass spectrometry[J].J Mass Spectrom,2015,50(10):1157
[56] PAINE MR,KIM J,BENNETT RV,et al.Whole reproductive system non-negative matrix factorization mass spectrometry imaging of an early-stage ovarian cancer mouse model[J].PLoS One,2016,11(5):1
[57] JARMUSCH AK,PIRRO V,BAIRD Z,et al.Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS[J].Proc Natl Acad Sci USA,2016,113(6):1486
[58] TATA A,GRIBBLE A,VENTURA M,et al.Wide-field tissue pol-arimetry allows efficient localized mass spectrometry imaging of biological tissues[J].Chem Sci,2016,7(3):2162
[59] SHEN L,ZHANG J,YANG Q,et al.High throughput paper spray mass spectrometry analysis[J].Clin Chim Acta,2013,420:28
[60] GOMEZ-RIOS GA,REYES-GARCES N,BOJKO B,et al.Biocom-patible solid-phase microextraction nanoelectrospray ionization:an unexploited tool in bioanalysis[J].Anal Chem,2016,88(2):1259
[61] SNYDER DT,PULLIAM CJ,OUYANG Z,et al.Miniature and fieldable mass spectrometers:recent advances[J].Anal Chem,2016,88(1):2

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