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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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双特异性抗体研发进展

Development in bispecific antibody

作者(英文):
分类号:R917
出版年·卷·期(页码):2019,39 (1):78-85
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

双特异性抗体(bsAb)因可同时特异性结合2个不同抗原表位,拓展了治疗性单克隆抗体的临床应用范围。制备bsAb需要对传统的抗体结构进行改造,在此过程中衍生出了数十种结构,不同的结构具有不同的作用特点。本综述就当前典型的bsAb结构及其原理进行介绍,对bsAb的作用原理进行分析,并对当前代表性的bsAb的研发阶段进行了简单总结。

-----英文摘要:---------------------------------------------------------------------------------------

The clinical application of therapeutic monoclonal antibody has been extended by bispesific antibody (bsAb)due to their capacity of binding two different antigenic epitopes.Structure changing would be needed for the construction of bsAb.There are several tens of bsAb structures developed,the specific action characteristics of which are related with their unique bsAb structure.In this review,typical structures and acting principles of bsAb were introduced,the action principle of bsAb was analyzed,and the development stages of representative bsAb were briefly summarized.

-----参考文献:---------------------------------------------------------------------------------------

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