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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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基于多元药效成分综合分析川麦冬适宜采收期研究

Study on the best harvest time of Ophiopogonis Radix from Sichuan based on the bioactive constituents

作者(英文):
分类号:R917
出版年·卷·期(页码):2018,38 (11):2021-2028
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:考察不同采收期川麦冬内在多元药效成分的动态变化规律,探讨川麦冬最佳采收期。方法:采用《中华人民共和国药典》2015年版规定的冷浸法对麦冬水浸出物含量进行测定;采用超声提取,以HPLC-MS对麦冬皂苷D、D',麦冬黄烷酮C、E,甲基麦冬黄烷酮A、B,甲基麦冬黄酮A的含量进行测定,用主成分分析法进行综合评价。结果:不同采收期川麦冬内在多元药效成分的含量呈现动态变化规律,综合评价显示,3月下旬采收的样品综合评价指数最高,与当地传统采收期基本相符。结论:本文为揭示川麦冬中多元药效成分的动态积累规律及确定其药材的适宜采收期提供基础资料,同时也为川麦冬内在质量的综合评价提供一定科学依据。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To study the dynamic change of bioactive constituents in Ophiopogonis Radix from Sichuan at different harvesting time,and to explore the optimal harvest period of Ophiopogonis Radix. Methods: The cold water extract was measured by the methods which are recorded in Chinese Pharmacopoeia. The contents of ophiopogonin D,ophiopogonin D',ophiopogonaone C,ophiopogonaone E,methylophiopogonanone A,methylophiopogonanone B and methylophiopogonone A were determined by HPLC-MS. And principal component analysis(PCA) was used for comprehensive evaluation. Results: There were obvious differences among the contents of active ingredients at different collecting time,and PCA results showed that Ophiopogonis Radix harvested around the late march and had the highest evaluation index,which was consistent with the local traditional harvest period. Conclusion: The result revealed the dynamic accumulation pattern of eight bioactive constituents in Ophiopogonis Radix from Sichuan Province and provided the basis for the suitable harvest time. Meanwhile,it provides certain scientific basis for quality evaluation of Ophiopogonis Radix.

-----参考文献:---------------------------------------------------------------------------------------
[1] 中华人民共和国药典2015年版.一部[S].2015:97 ChP 2010.Vol Ⅰ[S].2015:97
[2] 王远,王宇光,马增春,等.麦冬皂苷D通过降低自噬抑制血管紧张素Ⅱ诱导的心肌肥大[J].中国药理学通报,2016,32(10):1370 WANG Y,WANG YG,MA ZC,et al.Ophiopogonin D attenuates angiotensinⅡ-induced myocardial hypertrophy by reducing autophagy[J].Chin Pharmacol Bull,2016,32(10):1370
[3] 任思嘉,徐焕华,李明,等.麦冬皂苷D'对大鼠心肌细胞H9c2的细胞毒性[J].中国药理学与毒理学杂志,2017,31(4):325 REN SJ,XU HH,LI M,et al.Cytotoxicity of ophiopogonin D' for rat H9c2 cardiomyocytes[J].Chin J Pharm Toxicol,2017,31(4):325
[4] 吴发明,张思荻,曾俊,等.HPLC-ELSD法测定不同产地麦冬中4种代表性成分的含量[J].药物分析杂志,2016,36(8):1370 WU FM,ZHANG SD,ZENG J,et al.Determination of the 4 representative components in Maidong from different producing areas by HPLC-ELSD method[J].Chin J Pharm Anal,2016,36(8):1370
[5] 王菲,尚展鹏,马志国,等.不同干燥方法对川麦冬甾体皂苷和高异黄酮的影响[J].中国中药杂志,2016,41(23):4393 WANG F,SHANG ZP,MA ZG,et al.Influence of different drying methods on steroidal saponins and homoisoflavonoids in Ophiopogon japonicus[J].China J Chin Mater Med,2016,41(23):4393
[6] 席啸虎,刘瑢,刘霞.基于化学成分变化优化麦冬硫熏工艺[J].中草药,2017,48(7):1327 XI XH,LIU R,LIU X.Optimization of processing technology for sulfur smoked Ophiopogon japonicus based on changes in chemical composition[J].Chin Tradit Herb Drugs,2017,48(7):1327
[7] 于晓文,杜鸿志,孙立,等.麦冬皂苷药理作用研究进展[J].药学进展,2014,38(4):279 YU XW,DU HZ,SUN L,et al.Research progress in the pharmacological effects of ophiopogonins[J].Prog Pharm Sci,2014,38(4):279
[8] 熊双丽,李安林,黄妮.绵麦冬皂苷的提取分离及免疫活性研究[J].林产化学与工业,2015,35(1):121 XIONG SL,LI AL,HUANG N.Extraction,separation,and immunoregulatory activity of saponins from Ophiopogon japonicus(L.f) Ker-Gawl.[J].Chem Ind Fore Prod,2015,35(1):121
[9] 童菊华,庞小存,王威,等.杭麦冬与川麦冬中高异黄酮类成分和抗氧化活性的比较[J].中草药,2015,46(20):3091 TONG JH,PANG XC,WANG W,et al.Comparison of homoisoflavones extracted from Ophiopogon japonicus in Sichuan and Zhejiang and their anti-oxidative activity[J].China Tradit Herb Drugs,2015,46(20):3091
[10] 姜醒,王兴焱,张春蕾,等.麦冬中具有生物活性的高异黄酮类化学成分研究[J].中国现代中药,2017,19(4):491 JIANG X,WANG XY,ZHANG CL,et al.Bioactive homoisoflavonoids from tuber of Ophiopogon japonicus[J].Mod Chin Med,2017,19(4):491
[11] 刘伟.绵阳市三台县麦冬产业竞争力分析[D].成都:四川农业大学,2014 LIU W.Analysis of Competitiveness of Santai's Radix Ophiopogonis Industry[D].Chengdu:Sichuan Agricultural University,2014
[12] 蒋畅,王远,秦民坚,等.不同采收期及加工条件对川麦冬总黄酮和总皂苷含量的影响[J].中国中药杂志,2010,35(7):821 JIANG C,WANG Y,QIN MJ,et al.Influence of harvest times and processing methods on contents of total flavonoids and tota1 saponins in roots of Ophiopogon japonicus[J].China J Chin Mater Med,2010,35(7):821
[13] 姜国志,孙胜斌,刘铁军,等.参麦注射液用麦冬药材不同采收期的研究[J].现代中药研究与实践,2013,27(6):24 JIANG GZ,SUN SB,LIU TJ,et al.Study on harvest time of Dwarf lilyturf Tuber for Shenmai injection manufacturing[J].Chin Med J Res Pract,2013,27(6):24
[14] 吴茵.基于液质联用技术的麦冬化学成分分析与药代动力学研究[D].石家庄:河北医科大学,2015 WU Y.Studies on Chemical Composition Analysis and Pharmacokinetics of Radiz Ophiopogonis Based on LC-MS/MS Technology[D].Shijiazhuang:Hebei Medical University,2015
[15] 吴茵,魏欣,张黎媛,等.HPLC-MS/MS法同时测定参麦注射液7种主要有效成分[J].中草药,2014,45(18):2625 WU Y,WEI X,ZHANG LY,et al.Simultaneous determination of seven components in Shenmai injection by HPLC-MS/MS[J].China Tradit Herb Drugs,2014,45(18):2625
[16] 雷飞益,马留辉,吴海军,等.干燥方法对川麦冬药材品质的影响[J].中药材,2017,40(5):1077 LEI FY,MA LH,WU HJ,et al.Effects of different drying methods on chemical profile of Ophiopogon japonicus roots[J].J Chin Med Mater,2017,40(5):1077
[17] 齐红,王云,郭庆梅,等.不同采收期皱皮木瓜质量动态分析[J].中国实验方剂学杂志,2017,23(2):19 QI H,WANG Y,GUO QM,et al.Dynamic quality analysis of Chaenomelis Fructus in different harvesting periods[J].Chin J Exp Tradit Med Form,2017,23(2):19
[18] 罗益远,刘娟秀,刘训红,等.不同采收期何首乌中多元功效物质的动态积累分析[J].中国中药杂志,2015,40(13):2565 LUO YY,LIU JX,LIU XH,et al.Dynamic accumulation analysis of bioactive constituents of Polygonum multiflorum in different collection periods[J].China J Chin Mater Med,2015,40(13):2565
[19] 余欣洋,张丽艳,谢宇,等.主成分分析确定头花蓼最佳采收时间及初加工方法[J].中国实验方剂学杂志,2013,19(21):90 YU XY,ZHANG LY,XIE Y,et al.Principal component analysis to determine optimal harvesting time of Polygonum capitatum and initial processing method[J].Chin J Exp Tradit Med Form,2013,19(21):90
[20] 于京平,张永清,林海燕,等.栝楼果皮中腺嘌呤、鸟苷、瓜氨酸动态积累规律研究[J].天然产物研究与开发,2015,27(6):1032 YU JP,ZHANG YQ,LIN HY,et al.Dynamic accumulation of adenine,guanine nucleoside and citrulline in Trichosanthes kirilowii peel[J].Nat Prod Res Dev,2015,27(6):1032
[21] 刘和平,许彦,尚强,等.不同采收期水栀子果实中西红花苷Ⅰ、西红花苷Ⅱ和栀子苷含量变化研究[J].天然产物研究与开发,2017,29(8):1333 LIU HP,XU Y,SHANG Q,et al.Content variations of crocinⅠ,crocinⅡand gardenoside in Gardenia jasminoides var.grandiflora with different harvesting time[J].Nat Prod Res Dev,2017,29(8):1333
[22] 段金廒,严辉,宿树兰,等.药材适宜采收期综合评价模式的建立与实践[J].中草药,2010,41(11):1755 DUAN JA,YAN H,SU SL,et al.Establishment and practice for evaluating model of best harvest time of traditional Chinese medicinal materials[J].China Tradit Herb Drugs,2010,41(11):1755

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