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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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岗松、大叶桉及其药对中挥发油透皮成分的气相色谱-质谱联用分析

Analysis of transdermal components in volatile oil from Baeckea frutescens L.,Eucalyptus robusta Smith and their herb couple by GC-MS

作者(英文):
分类号:R917
出版年·卷·期(页码):2018,38 (11):1939-1944
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:对岗松、大叶桉及其药对中的挥发油进行透皮实验,考察配伍、透皮前后化学成分的变化。方法:采用水蒸气蒸馏法提取岗松、大叶桉药对及单味药材的挥发油,再采用Franz扩散池法进行体外透皮实验,并用GC-MS法进行分析。结果:透皮接收液中鉴定出岗松11个成分、大叶桉17个成分、药对12个成分,分别占挥发油总量的97.03%、91.77%、98.62%;1,8-桉叶素(28.63%)、芳樟醇(14.50%)、4-松油醇(31.83%)、α-松油醇(15.80%)等是岗松油的主要透皮成分;α-蒎烯(41.86%)、1,8-桉叶素(12.48%)、α-松油醇(13.99%)、4-松油醇(6.49%)等是大叶桉油的主要透皮成分;1,8-桉叶素(50.81%)、4-松油醇(16.98%)、α-松油醇(17.43%)、芳樟醇(5.79%)等是药对油的主要透皮成分。结论:药对油的成分不是两味药油的直接相加;岗松油、大叶桉油及药对油的化学成分的相对含量在透皮前后均有较大变化,氧化芳樟醇、1,8-桉叶素、芳樟醇、4-松油醇、α-松油醇等醇类物质更容易透过皮肤,而烯类透过性差。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To conduct the transdermal test of the volatile oil from Baeckea frutescens L.,Eucalyptus robusta Smith and their couplet medicines by GC-MS,and investigate the composition changes before and after combination and transdermal.Methods: The volatile oil from Baeckea frutescens L.,Eucalyptus robusta Smith and their couplet medicines were extracted by steam distillation.The permeation test in vitro was performed by Franz diffusion cell method and analyzed by GC-MS.Results: 11 components were identified in Baeckea frutescens L.(97.03%),17 components were identified in Eucalyptus robusta Smith(91.77%) and 12 components were identified in their couplet medicines(98.62%);The main transdermal components in Baeckea frutescens L. were 1,8-cineole(28.63%),linalol(14.50%),terpineol-4-ol(31.83%),α-terpineol(15.80%),etc.;The main transdermal components in Eucalyptus robusta Smith were α-pinene(41.86%),1,8-cineole(12.48%),α-terpineol(13.99%),terpineol-4-ol(6.49%),etc.;The main transdermal components in couplet medicines were 1,8-cineole(50.81%),terpineol-4-ol(16.98%),α-terpineol(17.43%),linalol(5.79%),etc..Conclusion: The compositions of the couplet medicines oil are not the direct addition of the components in separate herbs;The relative content of components in the oil of Baeckea frutescens L.,Eucalyptus robusta Smith and their couplet medicines were changed greatly before and after transdermal.It is easier for the alcohols like linalool oxide, 1,8-cineole,linalol,terpineol-4-ol and α-terpineol,ect. to penetrate through the skin.And the alkenes showed weak permeability.

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